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. 2015 Jul 31;10(7):e0134120. doi: 10.1371/journal.pone.0134120

Fig 6. TODRA lncRNA plays a role in a new feedback loop regulating RAD51 expression and activity.

Fig 6

E2F1 induction enhances RAD51 expression (thin green arrow) while simultaneously reducing lncRNA TODRA expression. While E2F1 induction of RAD51 is synergistically enhanced by TPIP (thick green arrow), E2F1 induction also reduces TPIP expression, possibly by affecting TODRA expression, as TODRA expression can increase TPIP expression. This feedback regulation of RAD51 expression can fine-tune RAD51 expression and HR-DSB repair. Green: Enhancement of expression/activity. Red: Suppression of expression/activity.