Table 3. Associations between alcohol and gene expression.
| Gene | Average Adjusted Count, Low Tertile Group | Average Adjusted Count, High Tertile Group | Fold Change | P Value 1 | Q Value 2 | Function/known pathways or disease relationships |
|---|---|---|---|---|---|---|
| Total Alcohol | ||||||
| KDELR1 | 51.32 | 71.20 | 1.39 | 3.63E-05 | 0.076 | Induces phyphorylation of p38 MAP kinases and may impact outcome of ER stress response |
| CPNE2 | 23.02 | 42.18 | 1.83 | 7.55E-05 | 0.092 | Encodes a calcium dependent protein; regulation of tumor necrosis factor |
| CACNA1C | 27.52 | 50.72 | 1.84 | 4.28E-05 | 0.076 | Cellular calcium ion homeostasis; cell-to-cell sginaling; regulation of hormone levels such as insulin; mood disorders and biopolar disease |
| KNTC1 | 54.14 | 34.24 | 0.63 | 5.00E-05 | 0.076 | Regulation of cell cycle process; personality disorders; diabetes |
| HELZ | 3579.58 | 19213.39 | 5.37 | 3.82E-06 | 0.023 | Alter biologic activity of RNA; mediates MAPK signaling |
| Beer | ||||||
| RRN3 | 20.13 | 38.32 | 1.90 | 1.48E-06 | 0.017 | Required for efficient transcription inition by RNA polymerase I; ERKA and AKT activation (mTOR- signaling pathway |
| IL13 | 0.28 | 3.13 | 11.18 | 2.84E-05 | 0.083 | Inflammatory response; this cytokine isdown regulates macrophage activity thereby inhibits the production of pro-inflammatory cytokines and chemokines. Involved in ERK signaling and AKT signaling PAK Pathway; asthma |
| DNAJB13 | 0.85 | 3.44 | 4.04 | 1.90E-05 | 0.067 | Apoptosis; protein folding; gamete generation; |
| DCUN1D3 | 5.64 | 11.84 | 2.10 | 1.10E-05 | 0.048 | Negative regulation of cell growth; positive regulation of apoptotic process; response to radiation |
| OR2C3 | 0.08 | 3.16 | 39.85 | 1.99E-06 | 0.017 | Cell surface receptor linked signal transduction; neurological system process; cognition; Olfactory Signaling Pathway; Signaling by G protein coupled receptors (GPCR) |
| PSMB10 | 15.16 | 6.96 | 0.46 | 7.25E-06 | 0.042 | Endopeptidase activity; immune response; metabolioc processes; cell cycle, mitotic pathways |
| Wine | ||||||
| SMOX | 2.10 | 7.80 | 3.72 | 5.62E-07 | 0.010 | Cellular functions including scavenging reactive oxygen species; neurotransmission; oxodpredictase activity; Involved in cytochrome p450 pathways; biological oxidation pathway; and metabolism |
| UPK1B | 3.16 | 0.42 | 0.13 | 1.86E-05 | 0.065 | Member of tetraspanin family; structural molecular activity; epithelial cell differentiation |
| DTD2 | 11.88 | 5.50 | 0.46 | 3.26E-05 | 0.095 | tRNA metabolic process regulation of translation fideltiy; hydrolase activity |
| KIAA1715 | 56.16 | 38.18 | 0.68 | 7.40E-06 | 0.050 | Blood coagulation; hemostatsis, response to wounding |
| C4orf51 | 0.36 | 3.37 | 9.46 | 1.31E-05 | 0.057 | Not available |
| MTRNR2L9 | 3.66 | 12.26 | 3.35 | 8.53E-06 | 0.050 | Neuroprotective and antipoptotic factor |
| Liquor | ||||||
| CXCL2 | 6.44 | 1.31 | 0.20 | 3.03E-06 | 0.024 | Chemokine activity; immune response; inflammatory response; chemokine signaling; signaling by GPCR |
| RBBP7 | 43.96 | 29.27 | 0.67 | 2.48E-05 | 0.097 | Cell proliferation; negative regulation of transcritpion from RNA polymerase II promoter; packaging of telomere ends; Development NOTCH1-mediated pathway for NFKB activity |
| SLC5A12 | 11.17 | 8.87 | 0.79 | 8.95E-07 | 0.014 | Symporter activity; ion transport; |
| CACNA1C | 29.31 | 51.19 | 1.75 | 2.44E-05 | 0.097 | Cellular calcium ion homeostasis; cell-to-cell sginaling; regulation of hormone levels such as insulin; mood disorders and biopolar disease |
1P values are raw p values
2Q Value is the smallest FDR at which this gene is called significant.