Table 4. Diet and oxidative balance score associated with differences in gene expression between the upper and lower tertile of expression where the False Discovery Rate (FDR) was set to <0.10.
| Gene | Average Adjusted Count, Low Tertile Group | Average Adjusted Count, High Tertile Group | Fold Change | P Value 2 | Q Value 3 | Function/known pathways or disease relationships |
|---|---|---|---|---|---|---|
| Beta Carotene | ||||||
| GPR52 | 4.48 | 9.46 | 2.11 | 3.25E-06 | 0.057 | Cell surface receptor linked signal transduction, G-protein coupled receptor (GPCR) protein signaling pathway |
| Lutein/Zeazanthine | ||||||
| PSMD5 | 19.37 | 28.65 | 1.48 | 4.27E-05 | 0.096 | Cell Cycle processes; protein binding involved in protein folding; Parkin-Ubiquitin Proteasomal System Pathway |
| KIAA0247 | 92.37 | 67.78 | 0.73 | 6.12E-05 | 0.096 | Biological Processes |
| CEBPZ | 36.19 | 57.57 | 1.59 | 1.38E-05 | 0.096 | Transcription regulation; DNA binding; direct p53 effectors pathway |
| EXOG | 15.68 | 22.09 | 1.41 | 4.37E-05 | 0.096 | Endonuclease activity; nucleic acid binding; hydrolase activity |
| SERPINA1 | 64.53 | 29.45 | 0.46 | 5.76E-05 | 0.096 | Response to hypoxia; acute inflammatory response; defense response; pathways include hemostasis and FOXA1 transcription factor network |
| Vitamin E | ||||||
| DAPP1 | 8.84 | 17.73 | 2.01 | 2.95E-05 | 0.097 | Protein amino acid dephosphorylation; |
| SEPT6 | 29.29 | 48.49 | 1.66 | 1.03E-05 | 0.097 | Cytokinesis, cell cycle; cell division; required for normal organization of the actin cytoskeleton; associated with acute myeloid leukemia; pathway include bacterial invasion of epithelial cells |
| CSGALNACT1 | 6.65 | 13.28 | 2.00 | 2.92E-05 | 0.097 | Metabolic processes; glucuronsyltransferase activity |
| HCLS1 | 29.73 | 47.28 | 1.59 | 1.78E-05 | 0.097 | Protein kinase binding; antigen receptor-coupled tyrosine kinase; response to hormones; pathways include immune response Fc epsilon RI pathway |
| NSAIDS | ||||||
| TMCO6 | 9.89 | 18.47 | 1.87 | 1.81E-05 | 0.09 | Protein transporter activity; intracellular protein transport |
| ST8SIA4 | 11.59 | 6.25 | 0.54 | 4.47E-06 | 0.05 | Cellular protein metabolic process; nervous system development protein linked glycosylation |
| STEAP3 | 14.53 | 22.99 | 1.58 | 2.51E-05 | 0.09 | Metal ion binding; apoptotic process; cell cycle; TP53 signaling pathway |
| Oxidative Balance Score | ||||||
| SYCP3 | 16.27 | 28.24 | 1.74 | 1.48E-06 | 0.026 | Cell Cycle Process; cell division; DNA binding |
| HDX | 2.77 | 5.08 | 1.84 | 1.56E-05 | 0.091 | Regulation of transcription; DNA binding |
| NRG4 | 5.61 | 11.27 | 2.01 | 8.55E-06 | 0.075 | Growth factor activity |
1No differentially expressed genes with FDR <0.1 identified for Vitamin C and lycopene
2P values are raw p values
3Q Value is the smallest FDR at which this gene is called significant.