Table 2.

Correlations of weight change from baseline to 6 and 12 months with changes in bone turn over markers and bone mineral density over the same period

At 6 months
	Weight change	BALP	Osteocalcin	PINP	CTX	NTX	RANK	RANKL	T-score	BMD Lumbar	BMD Pelvis
Weight change	1.00	0.09 0.48	−0.06 0.64	−0.17 0.15	−0.10 0.43	−0.18 0.14	0.13 0.35	−0.11 0.38	N/A	N/A	N/A
BALP		1.00	0.44 <0.01	0.53 <0.01	0.26 0.03	0.03 0.78	0.12 0.37	−0.02 0.87	N/A	N/A	N/A
Osteocalcin			1.00	0.69 <0.01	0.37 <0.01	0.00 0.97	0.11 0.40	−0.06 0.66	N/A	N/A	N/A
PINP				1.00	0.35 <0.01	0.01 0.94	0.05 0.73	0.04 0.74	N/A	N/A	N/A
CTX					1.00	0.08 0.53	−0.05 0.72	−0.20 0.13	N/A	N/A	N/A
NTX						1.00	0.02 0.90	0.01 0.96	N/A	N/A	N/A
RANK							1.00	−0.13 0.35	N/A	N/A	N/A
RANKL								1.00	N/A	N/A	N/A
At 12 months
Weight change	1.00	0.18 0.15	−0.04 0.74	−0.17 0.15	−0.22 0.07	0.02 0.90	0.26 0.04	−0.15 0.23	−0.25 0.04	−0.21 0.08	0.14 0.25
BALP		1.00	0.31 0.01	0.37 <0.01	0.27 0.02	−0.08 0.49	−0.06 0.67	−0.08 0.51	−0.29 0.02	0.03 0.81	−0.21 0.09
Osteocalcin			1.00	0.64 <0.01	0.37 <0.01	−0.01 0.90	0.05 0.73	0.18 0.17	0.07 0.56	0.04 0.74	−0.02 0.87
PINP				1.00	0.51 <0.01	−0.02 0.87	−0.08 0.53	0.03 0.83	−0.12 0.32	−0.14 0.24	−0.01 0.93
CTX					1.00	0.02 0.89	−0.03 0.80	−0.11 0.38	0.07 0.55	0.05 0.65	0.04 0.76
NTX						1.00	0.09 0.48	−0.04 0.76	−0.03 0.81	0.04 0.76	0.05 0.68
RANK							1.00	−0.01 0.93	−0.03 0.81	−0.27 0.04	0.12 0.37
RANKL								1.00	0.06 0.64	0.01 0.94	−0.18 0.16
T-score									1.00	0.05 0.65	0.15 0.22
BMD Lumbar										1.00	0.08 0.51
BMD Pelvis											1.00

P-values are presented below the Pearson correlation coefficients

BALP - bone-specific alkaline phosphatase

PINP - procollagen type I N-terminal propeptide

NTX - N-telopeptides of type-I collagen

RANK - receptor activator factor–kappa B

RANKL - receptor activator factor–kappa B ligand

BMD – Bone mineral density

N/A Not Available