Table 3.

Changes in weight, bone turn over markers and bone mineral density from baseline^*

	Baseline	6 months	Change	% Change	P-value	12 months	Change	% Change	P-value
Weight, lbs.	189.15	183.58	−5.57	−2.95 %	<0.01	184.90	−4.25	−2.25 %	<0.01
BALP, ug/L	16.87	17.94	1.07	6.34%	0.03	17.46	0.59	3.50%	0.21
Osteocalcin, ng/mL	19.10	18.58	−0.52	−2.72%	0.29	17.08	−2.02	−10.58%	<0.01
PINP, ng/mL	54.67	54.37	−0.30	−0.55%	0.89	46.73	−7.94	−14.52%	<0.01
CTX, ng/mL	0.58	0.59	0.01	1.72%	0.65	0.55	−0.03	−5.17%	0.26
NTX, nM BCE/L	19.05	18.40	−0.64	−3.36%	0.54	15.39	−3.65	−19.16%	<0.01
RANK, pg/mL	28.00	15.95	−12.05	−43.04%	<0.01	14.42	−13.58	−48.50%	<0.01
RANKL, pmol/L	146.40	150.77	4.37	2.98%	0.65	125.66	−20.74	−14.17%	<0.01
T-score	0.90					0.89	0.01	1.11%	0.88
BMD Lumbar	1.08					1.09	−0.01	−0.93%	0.58
BMD Pelvis	1.18					1.17	0.01	0.85%	0.46

^*Mean estimates and p-values based on Generalized Estimating Equation models

BALP - bone-specific alkaline phosphatase

PINP - procollagen type I N-terminal propeptide

NTX - N-telopeptides of type-I collagen

RANK - receptor activator factor–kappa B

RANKL - receptor activator factor–kappa B ligand

BMD – Bone mineral density