FIG. 2.

Overview of our algorithmic pipeline for characterization of pulmonary inflammation. Module 1: 3D histology volume is reconstructed from the 2D histology sections using ex vivo MRI as a conduit; the reconstruction also results in the generation of a 3D map of inflammation (yellow). Module 2: Volumetric coregistration of 3D histology and in vivo MRI volumes allows for the mapping of inflammation onto in vivo imaging. Module 3: Computer extracted image features of inflammation can then be identified from the in vivo MRI.