Table 3.
Median (IQR) changes from baseline to month 6 of follow-up in laboratory values of patients switched to a single-table regimen (STR) of rilpivirine, tenofovir and emtricitabine (RTE)
| Overall (n=238) | p | On a PI-based regimen at baseline (n=136) | p | On a PI-sparing regimen at baseline (n=102) | p | |
|---|---|---|---|---|---|---|
| CD4+ count (cells/µL) | 32 (−51–105) | 0.008 | 21 (−51–104) | 0.082 | 43 (−50–105) | 0.053 |
| CD4 + /CD8 + | 0.06 (−0.03–0.14) | 0.0004 | 0.07 (−0.02–0.15) | 0.002 | 0.05 (−0.07–0.13) | 0.126 |
| AST (UI/L) | 5 (−1–11) | <0.0001 | 6 (0–14) | <0.0001 | 4 (−3–9) | 0.006 |
| ALT (UI/L) | −5 (−19–3) | <0.0001 | −11 (−26 to −1) | <0.0001 | −3 (−10–5) | 0.295 |
| ALP (UI/L) | −10 (−21–2) | <0.0001 | −6 (−18–5) | 0.027 | −13 (−23–2) | <0.0001 |
| FIB-4 | 0.07 (−0.06–0.29) | 0.003 | 0.08 (−0.06–0.30) | 0.031 | 0.07 (−0.06–0.29) | 0.053 |
| Gamma GT (UI/L) | −5 (−15–3) | <0.0001 | 1 (−5–8) | 0.645 | −15 (−26 to −8) | <0.0001 |
| Total bilirubin (mg/dL) | 0.06 (−0.69–0.27) | 0.198 | −0.42 (−1.83–0.4) | 0.001 | 0.20 (0.09–0.40) | <0.0001 |
| Direct bilirubin (mg/dL) | 0.03 (−0.08–0.10) | 0.006 | −0.06 (−0.28–0.08) | 0.101 | 0.07 (0.03–0.12) | <0.0001 |
| Indirect bilirubin (mg/dL) | 0 (−0.56–0.18) | 0.999 | −0.40 (−1.39–0.04) | <0.0001 | 0.14 (0.05–0.30) | <0.0001 |
| Creatinine (mg/dL) | 0.05 (−0.01–0.12) | <0.0001 | 0.03 (−0.03–0.10) | 0.042 | 0.07 (−0.01–0.14) | 0.0001 |
| eGFR (mL/min/1.73m2) | −4 (−11–1) | <0.0001 | −2 (−10–2) | 0.009 | −5 (−11–0) | <0.0001 |
| Glucose (mg/dL) | −2 (−10–7) | 0.187 | 1 (−7–10) | 0.826 | −3 (−11–2) | 0.017 |
| Total cholesterol (mg/dL) | −19 (−37 to –3) | <0.0001 | −18 (−35–0) | <0.0001 | −23 (−39 to −9) | <0.0001 |
| LDL cholesterol (mg/dL) | −5 (−22–8) | 0.033 | −4 (−21–11) | 0.332 | −9 (−24–5) | 0.054 |
| HDL cholesterol (mg/dL) | −7 (−12 to –2) | <0.0001 | −3 (−10–2) | 0.007 | −8 (−15 to −4) | <0.0001 |
| Total/HDL cholesterol | 0 (0–0) | 0.133 | 0 (0–0) | 0.424 | 0 (−0.14–0) | 0.286 |
| Triglycerides (mg/dL) | −17 (−47–1) | <0.0001 | −22 (−57–2) | <0.0001 | −13 (−29–7) | 0.001 |
| Calcium (mmol/L) | 0.01 (−0.09–0.09) | 0.315 | −0.02 (−0.09–0.05) | 0.109 | 0.01 (−0.09–0.10) | 0.892 |
| Phosphorus (mmol/L) | 0.03 (−0.11–0.14) | 0.082 | 0.02 (−0.12–0.13) | 0.328 | 0.03 (−0.10–0.15) | 0.169 |
| Dip stick urinary protein (mg/dL) | 0 (–5–0) | 0.419 | 0 (−5–0) | 0.201 | 0 (−3–5) | 0.999 |
PI: protease inhibitor; Hb: haemoglobin; PLT: platelet count; AST: aspartate amino transferase; ALT: alanine amino transferase; ALP: alkaline phosphatase; FIB-4: liver fibrosis index; Gamma GT: gamma glutamyl transferase; eGFR: estimated glomerular filtration rate; LDL: low-density lipoprotein; HDL: high-density lipoprotein. Statistically significant differences are shown in bold.