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. 2015 Aug 1;13:249. doi: 10.1186/s12967-015-0614-x

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© Ghebremariam et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 10 — Hierarchical clustering of over 700 genes that are significantly regulated during the process of lung inflammation and fibrosis. Total RNA was extracted from the lungs of bleomycin-injured animals that received vehicle or esomeprazole (prophylactic or therapeutic course) treatment. Subsequent Genechip microarray analysis of the rat exon revealed that several transcripts are differentially regulated by esomeprazole and the prophylactic esomeprazole treatment group closely clustered with uninjured sham group. S sham, P prophylactic esomeprazole, V vehicle, T therapeutic esomeprazole.