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. 2015 Aug 1;13:249. doi: 10.1186/s12967-015-0614-x

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© Ghebremariam et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — The PPI esomeprazole regulates ionizing radiation-induced changes in gene expression in primary lung epithelial cells cultured in 3D matrix. In a inhibition of the spike in the pro-inflammatory cytokines TNF-α, NFκB and IL-6 is shown. b shows downregulation of the proapoptotic protein p53 and c shows the upregulation of the antioxidant gene HO1 by esomeprazole. Data is Mean ± SEM from duplicate experiments. *p < 0.05 compared to vehicle.