Table 4.
Responsiveness of I-QOL and IUI across clinical criteria at week 12
| Change scorea | p-value | SRMsb | Effect size | |||||
|---|---|---|---|---|---|---|---|---|
| Number | Mean | SD | Lower limit | Upper limit | ||||
| TBSc Greatly improve | ||||||||
| - Abbreviated I-QOL | 186 | 34.62 | 22.78 | 31.33 | 37.92 | <0.001 | 1.52 | 1.87 |
| - Original I-QOL | 187 | 42.79 | 21.72 | 39.66 | 45.92 | <0.001 | 1.97 | 2.24 |
| - IUI | 186 | 0.37 | 0.27 | 0.33 | 0.41 | <0.001 | 1.37 | 2.56 |
| TBS Improved | ||||||||
| - Abbreviated I-QOL | 274 | 18.14 | 19.64 | 15.76 | 20.40 | <0.001 | 0.92 | 0.98 |
| - Original I-QOL | 274 | 22.80 | 19.82 | 20.40 | 25.08 | <0.001 | 1.15 | 1.21 |
| - IUI | 274 | 0.16 | 0.19 | 0.14 | 0.19 | <0.001 | 0.87 | 1.14 |
| TBS Not changed | ||||||||
| - Abbreviated I-QOL | 462 | 1.90 | 15.86 | 0.56 | 3.47 | 0.017 | 0.12 | 0.11 |
| - Original I-QOL | 462 | 2.20 | 13.84 | 0.98 | 3.51 | 0.004 | 0.16 | 0.12 |
| - IUI | 462 | 0.02 | 0.13 | 0.00 | 0.03 | 0.031 | 0.12 | 0.12 |
| TBS Worsened | ||||||||
| - Abbreviated I-QOL | 109 | −0.73 | 15.97 | −3.77 | 2.30 | 0.502 | −0.05 | −0.04 |
| - Original I-QOL | 109 | −1.09 | 14.01 | −3.75 | 1.57 | 0.376 | −0.08 | −0.06 |
| - IUI | 109 | −0.01 | 0.13 | −0.03 | 0.02 | 0.363 | −0.05 | −0.05 |
| Responderd 50 % = 0 (No) | ||||||||
| - Abbreviated I-QOL | 552 | 2.79 | 16.86 | 1.49 | 4.36 | <0.001 | 0.17 | 0.16 |
| - Original I-QOL | 552 | 2.82 | 14.89 | 1.65 | 4.19 | <0.001 | 0.19 | 0.16 |
| - IUI | 552 | 0.02 | 0.14 | 0.01 | 0.03 | <0.001 | 0.16 | 0.17 |
| Responder 50 % = 1 (Yes) | ||||||||
| - Abbreviated I-QOL | 470 | 22.47 | 23.09 | 20.34 | 24.49 | <0.001 | 0.97 | 1.19 |
| - Original I-QOL | 471 | 28.51 | 24.01 | 26.29 | 30.60 | <0.001 | 1.19 | 1.50 |
| - IUI | 470 | 0.23 | 0.25 | 0.20 | 0.25 | <0.001 | 0.90 | 1.52 |
| Responder 75 % = 0 (No) | ||||||||
| - Abbreviated I-QOL | 697 | 5.05 | 17.89 | 3.77 | 6.46 | <0.001 | 0.28 | 0.28 |
| - Original I-QOL | 697 | 5.85 | 17.29 | 4.61 | 7.20 | <0.001 | 0.34 | 0.32 |
| - IUI | 697 | 0.04 | 0.15 | 0.03 | 0.05 | <0.001 | 0.28 | 0.32 |
| Responder 75 % = 1 (Yes) | ||||||||
| - Abbreviated I-QOL | 325 | 26.40 | 23.65 | 23.85 | 28.94 | <0.001 | 1.12 | 1.41 |
| - Original I-QOL | 326 | 33.46 | 23.76 | 30.86 | 35.96 | <0.001 | 1.41 | 1.75 |
| - IUI | 325 | 0.28 | 0.27 | 0.25 | 0.31 | <0.001 | 1.05 | 1.80 |
| Responder 100 % = 0 (No) | ||||||||
| - Abbreviated I-QOL | 843 | 7.38 | 19.10 | 6.12 | 8.72 | <0.001 | 0.39 | 0.41 |
| - Original I-QOL | 843 | 9. 18 | 19.58 | 7.88 | 10.54 | <0.001 | 0.47 | 0.50 |
| - IUI | 843 | 0.06 | 0.17 | 0.05 | 0.08 | <0.001 | 0.38 | 0.48 |
| Responder 100 % = 1 (Yes) | ||||||||
| - Abbreviated I-QOL | 179 | 32.85 | 23.97 | 29.21 | 36.12 | <0.001 | 1.37 | 1.79 |
| - Original I-QOL | 180 | 40.26 | 22.99 | 36.69 | 43.30 | <0.001 | 1.75 | 2.10 |
| - IUI | 179 | 0.36 | 0.28 | 0.32 | 0.40 | <0.001 | 1.29 | 2.40 |
aChange score = scores at week 12 minus scores at baseline
bSRM: Standardized response means
cTBS: Treatment Benefit Scale
dResponder: calculated from the average percentage of reduction in daily UI episodes from baseline