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. 2015 Aug 1;15:570. doi: 10.1186/s12885-015-1575-4

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© Hennig et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The (Z)-endoxifen-directed metabolism of tamoxifen according to the association of its metabolites concentration with CYP2D6 genotype. The intensity of gray shading corresponds with the number of CYP2D6 genotype predicted functional groups with a significant (p < 6.9 × 10⁻⁴) association with metabolite plasma concentration. White indicates no association and black indicates association with three genotypes, as indicated by linear modeling (see Fig. 1)