Table 3.
The steady-state plasma concentration of tamoxifen and its metabolites
| [ng/ml] | Mean | SD | Median | Min | Max | Not detecteda |
|---|---|---|---|---|---|---|
| N = 279 (%) | ||||||
| Tamoxifen | 173.53 | 67.68 | 169.76 | 41.4 | 402.10 | 0 (0) |
| NDM-Tam | 235.53 | 97.04 | 220.53 | 33.20 | 810.16 | 0 (0) |
| (Z)-Endoxifen + 3-OH-NDM-Tam | 5.55 | 3.26 | 4.90 | 0.55 | 18.23 | 0 (0) |
| (Z)-4-OH-Tam + 3-OH-Tam | 2.46 | 1.20 | 2.45 | 0.12 | 5.66 | 0 (0) |
| (E)-Endoxifen | 0.02 | 0.07 | 0 | 0.03 | 0.37 | 249 (89.2) |
| 4′-OH-Tam | 3.13 | 1.32 | 2.93 | 0.37 | 8.72 | 0 (0) |
| 4′-OH-NDM-Tam | 3.84 | 1.93 | 3.56 | 0.19 | 15.66 | 1 (0.4) |
| Tam-N-oxide | 13.47 | 7.43 | 11.62 | 1.41 | 58.03 | 0 (0) |
| (E)-4-OH-Tam-O-gluc | 0.23 | 0.17 | 0.18 | 0.03 | 1.19 | 1 (0.4) |
| (E/Z)-4-OH-NDM-Tam-gluc | 1.12 | 1.02 | 0.88 | 0.10 | 11.49 | 0 (0) |
| (E/Z)-Tam-N-gluc | 0.32 | 0.32 | 0.24 | 0.03 | 2.45 | 1 (0.4) |
| (E)-α-OH-Tam | 0.36 | 0.17 | 0.37 | 0.02 | 1.02 | 8 (2.9) |
| (Z)-α-OH-Tam | 0.04 | 0.03 | 0.04 | 0.02 | 0.19 | 116 (41.6) |
aThe number and (%) of patients with no detectable plasma concentration of compounds