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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Transplantation. 2010 Jul 27;90(2):142–149. doi: 10.1097/TP.0b013e3181e228db

Figure 5. Simvastatin prevents endothelial apoptosis during cold storage through a KLF2-dependent mechanism.

Figure 5

A) Expression of the apoptosis marker Annexin V in EC exposed for 24h to vasoprotective flow and statically cold stored for 0h or 6h in University of Wisconsin Solution supplemented with simvastatin or its vehicle (* p<0.05 vs. 0h and 6h simvastatin. n=4). B) Representative flow cytometry histogram of Annexin V expression determined in EC described above. C) Expression of Annexin V in EC transfected with specific KLF2 siRNA or control, cultured for 24h under vasoprotective flow and statically cold preserved for 0h or 6h with simvastatin or its vehicle (*p<0.05 vs. ctrl siRNA 0h and ctrl siRNA 6h vehicle. n=3).