Table 2.
Locations of the covariant decreases in grey matter volume and FA value in the AD patients compared to the NCs for joint ICs 1-3.
| Brain regions | Peak coordinates MNI (X,Y,Z) | Z | Cluster size (mm3) | Overlap ratio (%) | ||
|---|---|---|---|---|---|---|
| Joint IC 1, Grey matter (volume) | ||||||
| L Middle temporal gyrus | −43.5 | 12 | −36 | 12.71 | 17,814 | 39.1% |
| R Middle temporal gyrus | 36 | 9 | −42 | 11.30 | 11,485 | 25.8% |
| L Inferior temporal gyrus | −43.5 | 10.5 | −37.5 | 12.87 | 11,158 | 12.8% |
| R Inferior temporal gyrus | 36 | 7.5 | −42 | 11.62 | 9,163 | 9.3% |
| L Superior temporal gyrus | −27 | 10.5 | −34.5 | 9.56 | 5,738 | 16.3% |
| R Superior temporal gyrus | 28.5 | 12 | −34.5 | 8.45 | 3,584 | 10.0% |
| L Parahippocampal gyrus | −27 | −3 | −36 | 8.07 | 2,629 | 10.1% |
| R Parahippocampal gyrus | 24 | 3 | −30 | 7.52 | 3,949 | 13.1% |
| L Hippocampus | −24 | −6 | −22.5 | 8.63 | 2,079 | 8.3% |
| R Hippocampus | 24 | −1.5 | −24 | 8.74 | 1,492 | 5.9% |
| L Amygdala | −24 | −4.5 | −24 | 8.48 | 1,306 | 23.2% |
| R Amygdala | 24 | −3 | −22.5 | 8.70 | 1,239 | 18.8% |
| Joint IC 1, white matter (FA) | ||||||
| Cingulum (hippocampus) | −26 | −22 | −25 | 4.25 | 396 | 16.6% |
| L External capsule | −25 | 17 | 8 | 2.68 | 169 | 3.0% |
| L Anterior limb of internal capsule | −22 | 17 | 11 | 2.76 | 159 | 5.3% |
| L Anterior corona radiata | −24 | 18 | 10 | 2.70 | 80 | 1.2% |
| Joint IC 2, grey matter (volume) | ||||||
| L Middle frontal gyrus | −25.5 | 49.5 | 7.5 | 7.26 | 10,291 | 14.7% |
| R Middle frontal gyrus | 28.5 | 51 | 6 | 5.98 | 11,927 | 24.5% |
| L Superior frontal gyrus | −24 | 51 | 4.5 | 6.68 | 5,417 | 15.0% |
| R Superior frontal gyrus | 7.5 | 48 | −24 | 6.22 | 6,574 | 3.0% |
| L Inferior frontal gyrus | −30 | 39 | −15 | 6.38 | 3,216 | 7.0% |
| L Anterior cingulate gyrus | −7.5 | 48 | 3 | 7.03 | 3,952 | 10.6% |
| R Anterior cingulate gyrus | 7.5 | 33 | 21 | 5.44 | 4,823 | 13.3% |
| L Rectus | 0 | 37.5 | −18 | 6.17 | 3,173 | 13.5% |
| R Rectus | 6 | 46.5 | −24 | 6.37 | 3,203 | 15.5% |
| Joint IC 2, white matter (FA) | ||||||
| Body of corpus callosum | −7 | 17 | 19 | 4.76 | 1,891 | 13.8% |
| Genu of corpus callosum | −7 | 20 | 19 | 4.56 | 529 | 6.0% |
| Cingulum (cingulated gyrus) | −9 | 18 | 25 | 3.20 | 226 | 4.4% |
| R External capsule | 32 | 8 | −9 | 2.84 | 123 | 2.2% |
| Superior longitudinal fasciculus | −34 | −43 | 31 | 2.79 | 58 | 0.4% |
| Joint IC 3, grey matter (volume) | ||||||
| L Middle occipital gyrus | −36 | −78 | 39 | 10.39 | 10,301 | 39.3% |
| R Middle occipital gyrus | 40.5 | −73.5 | 39 | 11.62 | 8,188 | 48.9% |
| L Middle temporal gyrus | −43.5 | −66 | 18 | 9.32 | 9,005 | 22.7% |
| R Middle temporal gyrus | 45 | −69 | 22.5 | 8.85 | 5,130 | 14.6% |
| L Angular | −40.5 | −75 | 37.5 | 9.92 | 7,641 | 80.7% |
| R Angular | 39 | −70.5 | 43.5 | 12.34 | 7,911 | 56.0% |
| L Precuneus | 1.5 | −55.5 | 33 | 6.62 | 5,437 | 19.2% |
| R Precuneus | 6 | −52.5 | 36 | 7.43 | 7,155 | 27.6% |
| L Inferior parietal gyrus | −34.5 | −78 | 40.5 | 10.15 | 3,942 | 20.2% |
| L Superior parietal gyrus | −36 | −70.5 | 49.5 | 7.51 | 2,241 | 13.6% |
| R Middle frontal gyrus | 42 | 10.5 | 46.5 | 6.22 | 2,217 | 5.4% |
| L Post cingulate gyrus | −6 | −49.5 | 33 | 6.29 | 1,472 | 39.4% |
| Joint IC 3, white matter (FA) | ||||||
| Body of corpus callosum | −6 | −20 | 26 | 4.10 | 1,403 | 10.2% |
| Superior corona radiata | 17 | 13 | 31 | 3.19 | 641 | 4.3% |
| Posterior thalamic radiation | 28 | −55 | 16 | 2.94 | 401 | 5.0% |
| Superior longitudinal fasciculus | −40 | −42 | 12 | 4.27 | 387 | 2.9% |
| Posterior corona radiata | −27 | −30 | 30 | 3.46 | 189 | 2.5% |
| R Anterior corona radiata | 17 | 16 | 29 | 3.00 | 104 | 1.5% |
| Splenium of corpus callosum | 27 | −55 | 16 | 2.94 | 94 | 0.7% |
*L: left; R: right; MNI: Montreal Neurological Institute; Overlap ratio: the number of voxels in ROI of Atlas divided by that of suprathreshold voxels in the corresponding brain regions of significance maps.