Table 3.
Meta-analysis Results of Creatinine Clearance Associations (top 20 SNPs)
| GWAS (genotyped SNPs) | GWAS (imputed SNPs) | Candidate SNPs (from GWAS Catalog) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | chr | gene | Pa | SNP | chr | gene | Pa | SNP | chr | gene | Pc |
| rs121882 | 5 | ARHGAP26 | 1.2E-05 | rs2682618 | 12 | TMEM132B, TMEM132Cc | 4.8E-06 | rs10941692 | 5 | MRPS30, HCN1c | 2.6E-02 |
| rs4243086 | 15 | CYP11A1, SEMA7Ac | 1.5E-05 | rs34574970 | 9 | KLF9, TRPM3c | 9.1E-06 | rs7805747 | 7 | PRKAG2 | 2.8E-02 |
| rs9602954 | 13 | MOB1AP1, DDX6P2c | 1.5E-05 | rs34536198 | 1 | KIRREL | 9.6E-06 | rs12520150 | 5 | MRPS30, HCN1c | 4.0E-02 |
| rs3914576 | 15 | NDN, PWRN2c | 2.0E-05 | rs121882 | 5 | ARHGAP26 | 1.1E-05 | rs9473932 | 6 | TFAP2B, PKHD1c | 5.1E-02 |
| rs419129 | 6 | GSTA3, GSTA4c | 2.5E-05 | chr1:158038705:D | 1 | KIRREL | 1.1E-05 | rs2082424 | 19 | CEP89 | 5.6E-02 |
| rs17039196 | 4 | RAPGEF2, FSTL5c | 2.9E-05 | rs35676418 | 7 | AC005029.1, AC005022.1c | 1.2E-05 | rs7246178 | 19 | CEP89 | 5.9E-02 |
| rs17622266 | 7 | LINC01450 | 3.0E-05 | rs9602954 | 13 | MOB1AP1, DDX6P2c | 1.3E-05 | rs660895 | 6 | HLA-DQA1, HLA-DRB1c | 7.2E-02 |
| rs6963950 | 7 | AC005029.1, AC005022.1c | 3.0E-05 | rs4243086 | 15 | CYP11A1, SEMA7Ac | 1.4E-05 | rs17272197 | 19 | SLC7A9 | 1.5E-01 |
| rs7002294 | 8 | PVT1 | 4.0E-05 | rs7783070 | 7 | AC005029.1, AC005022.1c | 1.6E-05 | rs1133029 | 20 | SULF2, PREX1c | 1.5E-01 |
| rs7034027 | 9 | TRPM3 | 4.2E-05 | rs113869768 | 4 | RAPGEF2, FSTL5c | 1.8E-05 | rs653178 | 12 | ATXN2 | 1.5E-01 |
| rs2273289 | 1 | PLOD1 | 4.3E-05 | rs10780944 | 9 | TRPM3 | 2.0E-05 | rs2057291 | 20 | GNAS | 1.5E-01 |
| rs10758871 | 9 | KDM4C, TMEM261c | 4.5E-05 | rs4605427 | 20 | DOK5, CBLN4c | 2.0E-05 | rs6677604 | 1 | CFH | 1.6E-01 |
| rs1976756 | 15 | NDN, PWRN2c | 4.5E-05 | rs3914576 | 15 | PWRN4 | 2.3E-05 | rs4664308 | 2 | PLA2R1 | 2.4E-01 |
| rs7033976 | 9 | TRPM3 | 4.6E-05 | rs17039181 | 4 | RAPGEF2, FSTL5c | 2.6E-05 | rs16902083 | 5 | HCN1 | 2.5E-01 |
| rs3750494 | 9 | CDK5RAP2 | 4.7E-05 | rs72959075 | 4 | RAPGEF2, FSTL5c | 2.6E-05 | rs11705804 | 3 | LRIG1, SUCLG2c | 2.5E-01 |
| rs749074 | 14 | GPATCH2L | 5.5E-05 | rs4322895 | 20 | DOK5, CBLN4c | 2.6E-05 | rs1556751 | 9 | PIP5K1B | 2.5E-01 |
| rs4524177 | 20 | DOK5, CBLN4c | 5.6E-05 | rs4322896 | 20 | DOK5, CBLN4c | 2.6E-05 | rs11864909 | 16 | PDILT | 2.5E-01 |
| rs2682621 | 12 | TMEM132B, TMEM132Cc | 5.9E-05 | rs4619678 | 20 | DOK5, CBLN4c | 2.7E-05 | rs3925075 | 16 | ITGAM, ITGAXc | 2.6E-01 |
| rs11067378 | 12 | TBX3, MED13Lc | 6.4E-05 | rs4346453 | 20 | DOK5, CBLN4c | 2.7E-05 | rs16853741 | 3 | MECOM | 2.7E-01 |
| rs12701851 | 7 | LINC01450 | 6.7E-05 | rs4622788 | 20 | DOK5, CBLN4c | 2.7E-05 | rs2151421 | 9 | PIP5K1B | 2.8E-01 |
a
Significance threshold was 5×10−8 for the genome-wide analyses.
b Significance threshold was 0.0002 for the subset of 212 SNPs.
c
For intergenic SNPs, indicated are the nearest known gene 3′ and 5′ genes.