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. Author manuscript; available in PMC: 2016 Jul 31.
Published in final edited form as: Circ Res. 2015 Jun 1;117(4):e41–e53. doi: 10.1161/CIRCRESAHA.117.306457

Figure 3. KLF2 promotes PPAP2B expression by activating its promoter activity.

Figure 3

(A) KLF2 overexpression via adenoviral transduction increased PPAP2B protein in HAEC. (B) PPAP2B promoter drove Firefly luciferase reporter activity, compared with minimal promoter, which was further increased by KLF2 overexpression via plasmid transfection. (C-D) KLF2 expression was decreased in endothelial cells isolated from ligated mouse LCA (C) and in HAEC exposed to athero-susceptible waveform (D). All data are represented as mean ± SEM. n = 3-5. * P < 0.05, t-test.