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. Author manuscript; available in PMC: 2016 Jul 23.
Published in final edited form as: Chem Biol. 2015 Jul 9;22(7):907–916. doi: 10.1016/j.chembiol.2015.06.014

Figure 1. Simplified schematic of cyanobactin biosynthesis.

Figure 1

A schematic of cyanobactin biosynthetic machinery showing the leader peptide, core peptide, recognition sequences (RSs) and the posttranslational enzymes used in this study. ThcD is a heterocyclase that uses RSI to modify Cys residues to thiazoline. This is followed by the action of proteases PatA and PatG (or TruG) that use RSII and RSIII to cleave off the N- and C-termini of the core peptides respectively. PatG (or TruG) also carries out macrocyclization in tandem with proteolysis. The prenyltransferases TruF1 and PagF add isoprene units to the cyclic peptide scaffold and do not require RSs.