Skip to main content
. Author manuscript; available in PMC: 2015 Aug 2.
Published in final edited form as: Mol Cell Neurosci. 2010 Mar 23;44(2):190–200. doi: 10.1016/j.mcn.2010.03.007

Fig. 6. The effect of synapsin II and Rab3a on seizure and locomotor activity, with the epileptic seizures typical for Syn II(−) animals being partially rescued by the Rab3a gene deletion.

Fig. 6

A. WT and Rab3a (−) mice have no seizure activity, while Syn II (−) mice have prominent seizures. Syn II (−)/Rab3a (−) DKO animals have a very low frequency of seizures, demonstrating a partial rescue of the Syn II (−) phenotype by the Rab3a deletion. Each bar is the average of 4 separate trials. Data collected from 54 WT, 27 Rab3a (−), 18 Syn II (−), and 44 Syn II (−) / Rab3a (−) DKO mice. * p ≤ 0.05, *** p ≤ 0.0005

B. Rab3a (−) mice spend significantly more time resting than WT mice, while both the Syn II (−) and the Syn II (−)/Rab3a (−) DKO mice spend significantly more time moving than WT mice. Data was collected for 10 minutes in 10 s bins from 18 WT, 16 Rab3a (−), 16 Syn II (−), and 18 Syn II (−) / Rab3a (−) DKO mice. * p ≤ 0.05.