. Author manuscript; available in PMC: 2015 Aug 2.

Published in final edited form as: Mol Cell Neurosci. 2010 Mar 23;44(2):190–200. doi: 10.1016/j.mcn.2010.03.007

Table 1.

Effects of single and double deletions on different characteristics of synaptic transmission, ultrastructure, and behavior.

Characteristic	Rab3a (−)	SynII (−)	DKO
*1. Controlled by one protein independently of the other: the same characteristic appears in a single KO and in the DKO*
Docked vesicles	Decreased	Unchanged	Decreased
Intraterminal vesicles	Unchanged	Decreased	Decreased
Depression	Unchanged	Increased	Increased
Recovery from depression	Unchanged	Incomplete	Incomplete
*2. Opposing effects of Syn II and Rab3a compensate for each other in DKO*
Spontaneous synaptic activity	Decreased	Increased	Unchanged
*3. Rab3a loss precludes the effect of Syn II loss*
Quantal content	Decreased	Increased	Strongly decreased
Quantal content at low Ca²⁺	Strongly decreased	Strongly increased	Strongly decreased
Seizure activity	Unchanged	Increased	Slightly increased
*4. Syn II loss precludes the effect of Rab3a loss*
Locomotor activity	Decreased	Increased	Increased