Figure 2: Glutamatergic signaling cascades in renal tissue. Glutamate receptors NMDA-, AMPA- and metabotropic mGluR1 receptors, which are present and functional in tubular cells as well as podocytes, are depicted with potential associated signaling cascades ranging from calcium signaling to phospholipase and adenylate cyclase cascades and their interlinking pathways. Metabolites are depicted with a grey box, receptors in yellow, kinases in pink, phospholipases in orange, and phosphatases with a green box. Global parameters are shown with a blue box and scaffolders with a green ellipse.