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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: DNA Repair (Amst). 2015 May 1;32:66–74. doi: 10.1016/j.dnarep.2015.04.015

Figure 3.

Figure 3

Model for nick-initiated resection by MRN-CtIP at protein-occluded DSBs. Sae2/CtIP activates the MRX/MRN endonuclease activity to generate a nick, followed by bidirectional resection catalyzed by MRN in the 3′ to 5′ direction and EXO1 in the 5′ to 3′ direction.