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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Environ Toxicol Pharmacol. 2015 Jun 23;40(1):333–341. doi: 10.1016/j.etap.2015.06.016

Figure 1. Effect of intranasal manganese on the levels of manganese in different brain regions of Hfe-deficient mice.

Figure 1

Microdissected brain tissues, including prefrontal cortex, striatum, hippocampus and cerebellum, were collected from mice that were intranasally instilled with MnCl2 (5 mg/kg) or water. The steady-state concentrations of manganese were quantified by inductively coupled plasma mass spectrometry (ICP-MS; n = 7–8 per group). Empty and closed bars represent wild-type (Hfe+/+) and Hfe-deficient (Hfe−/−) mice, respectively. Data were presented as mean ± SEM and were analyzed using two-way ANOVA, followed by post-hoc comparisons. Hfe x Mn, an interaction effect between Hfe deficiency and olfactory Mn exposure.