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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Contemp Clin Trials. 2015 Jun 17;43:209–216. doi: 10.1016/j.cct.2015.06.008

Table 1. A Sample Randomization Procedure with Mass Weighted Urn Design.

Number of treatment arms = 3; Target Allocation = 1: 1: √2; Sample size n = 300; α = 4.

i Before Assignment During Assignment After Assignment
n i-1,1 n i-1,2 n i-1,3 p i,1 p i,2 p i,3 g i x i T i d i ni,2/ni,1 ni,3/ni,1
1 0 0 0 0.293 0.293 0.414 0 0.664 3 0.717
2 0 0 1 0.366 0.366 0.268 0.179 0.718 2 0.738
3 0 1 1 0.439 0.189 0.371 0.184 0.098 1 0.297 1 1
4 1 1 1 0.263 0.263 0.475 0.074 0.763 3 0.420 1 2
5 1 1 2 0.336 0.336 0.328 0.105 0.044 1 0.712 0.5 1
6 2 1 2 0.159 0.409 0.432 0.178 0.314 2 0.594 1 1
7 2 2 2 0.232 0.232 0.536 0.149 0.350 2 1.309 1.5 1
8 2 3 2 0.305 0.055 0.639 0.327 0.147 1 1.609 1 0.667
9 3 3 2 0.129 0.129 0.743 0.402 0.727 3 0.891 1 1
10 3 3 3 0.202 0.202 0.596 0.223 0.006 1 1.567 0.75 0.75
......
291 85 85 120 0.278 0.278 0.445 0.037 0.033 1 0.964 0.988 1.395
292 86 85 120 0.101 0.351 0.548 0.241 0.250 2 1.163 1 1.395
293 86 86 120 0.174 0.174 0.652 0.291 0.709 3 0.446 1 1.407
294 86 86 121 0.247 0.247 0.505 0.111 0.937 3 0.272 1 1.419
295 86 86 122 0.321 0.321 0.359 0.068 0.621 2 0.745 1.012 1.419
296 86 87 122 0.394 0.144 0.462 0.186 0.905 3 0.856 1.012 1.430
297 86 87 123 0.467 0.217 0.316 0.214 0.735 3 1.392 1.012 1.442
298 86 87 124 0.540 0.290 0.169 0.348 0.132 1 0.692 1 1.425
299 87 87 124 0.364 0.364 0.273 0.173 0.468 2 0.731 1.011 1.425
300 87 88 124 0.437 0.187 0.377 0.183 0.318 1 0.323 1 1.409

α: Parameter used by the mass weighted urn design.

i: Randomization sequence order.

ni-1,j: Treatment distribution before subject i. (j=1,2,3).

pi,j: Conditional allocation probability for subject i. (j=1,2,3)

gi: Allocation predictability for subject i.

xi: Random number

Ti: Treatment assignment for subject i.

di: Treatment imbalance for subject i.

di: Treatment imbalance after subject i.

ni,j/ni,1: Allocation ratio between arm j and 1, (j=2,3)