Table 1. A Sample Randomization Procedure with Mass Weighted Urn Design.
i | Before Assignment | During Assignment | After Assignment | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
n i-1,1 | n i-1,2 | n i-1,3 | p i,1 | p i,2 | p i,3 | g i | x i | T i | d i | ni,2/ni,1 | ni,3/ni,1 | |
1 | 0 | 0 | 0 | 0.293 | 0.293 | 0.414 | 0 | 0.664 | 3 | 0.717 | ||
2 | 0 | 0 | 1 | 0.366 | 0.366 | 0.268 | 0.179 | 0.718 | 2 | 0.738 | ||
3 | 0 | 1 | 1 | 0.439 | 0.189 | 0.371 | 0.184 | 0.098 | 1 | 0.297 | 1 | 1 |
4 | 1 | 1 | 1 | 0.263 | 0.263 | 0.475 | 0.074 | 0.763 | 3 | 0.420 | 1 | 2 |
5 | 1 | 1 | 2 | 0.336 | 0.336 | 0.328 | 0.105 | 0.044 | 1 | 0.712 | 0.5 | 1 |
6 | 2 | 1 | 2 | 0.159 | 0.409 | 0.432 | 0.178 | 0.314 | 2 | 0.594 | 1 | 1 |
7 | 2 | 2 | 2 | 0.232 | 0.232 | 0.536 | 0.149 | 0.350 | 2 | 1.309 | 1.5 | 1 |
8 | 2 | 3 | 2 | 0.305 | 0.055 | 0.639 | 0.327 | 0.147 | 1 | 1.609 | 1 | 0.667 |
9 | 3 | 3 | 2 | 0.129 | 0.129 | 0.743 | 0.402 | 0.727 | 3 | 0.891 | 1 | 1 |
10 | 3 | 3 | 3 | 0.202 | 0.202 | 0.596 | 0.223 | 0.006 | 1 | 1.567 | 0.75 | 0.75 |
...... | ||||||||||||
291 | 85 | 85 | 120 | 0.278 | 0.278 | 0.445 | 0.037 | 0.033 | 1 | 0.964 | 0.988 | 1.395 |
292 | 86 | 85 | 120 | 0.101 | 0.351 | 0.548 | 0.241 | 0.250 | 2 | 1.163 | 1 | 1.395 |
293 | 86 | 86 | 120 | 0.174 | 0.174 | 0.652 | 0.291 | 0.709 | 3 | 0.446 | 1 | 1.407 |
294 | 86 | 86 | 121 | 0.247 | 0.247 | 0.505 | 0.111 | 0.937 | 3 | 0.272 | 1 | 1.419 |
295 | 86 | 86 | 122 | 0.321 | 0.321 | 0.359 | 0.068 | 0.621 | 2 | 0.745 | 1.012 | 1.419 |
296 | 86 | 87 | 122 | 0.394 | 0.144 | 0.462 | 0.186 | 0.905 | 3 | 0.856 | 1.012 | 1.430 |
297 | 86 | 87 | 123 | 0.467 | 0.217 | 0.316 | 0.214 | 0.735 | 3 | 1.392 | 1.012 | 1.442 |
298 | 86 | 87 | 124 | 0.540 | 0.290 | 0.169 | 0.348 | 0.132 | 1 | 0.692 | 1 | 1.425 |
299 | 87 | 87 | 124 | 0.364 | 0.364 | 0.273 | 0.173 | 0.468 | 2 | 0.731 | 1.011 | 1.425 |
300 | 87 | 88 | 124 | 0.437 | 0.187 | 0.377 | 0.183 | 0.318 | 1 | 0.323 | 1 | 1.409 |
α: Parameter used by the mass weighted urn design.
i: Randomization sequence order.
ni-1,j: Treatment distribution before subject i. (j=1,2,3).
pi,j: Conditional allocation probability for subject i. (j=1,2,3)
gi: Allocation predictability for subject i.
xi: Random number
Ti: Treatment assignment for subject i.
di: Treatment imbalance for subject i.
di: Treatment imbalance after subject i.
ni,j/ni,1: Allocation ratio between arm j and 1, (j=2,3)