Table 2.

Association or pre-treatment pairwise combinations of ascites cytokine levels on PFS and OS in months (n=70)

IL-8 and IL-6	n	PFS (p=0.732)	OS (p=0.779)
IL-8low/IL-6low	22	15.2 (6.7-19.1)	26.1 (17.9-49.1)
IL-8low/IL-6high	13	14.4 (4.5-NA)	34.0 (23.2-NA)
IL-8high/IL-6low	12	11.1 (7.8-NA)	24.6 (13.1-NA)
IL-8high/IL-6high	23	6.5 (5.7-18.6)	27.8 (14.3-67.6)
TNF-α and IL-8	n	PFS (p=0.090)	OS (p=0.223)
TNF-αlow/IL-8low	19	15 (5.1-26.2)	26.3 (17.9-NA)
TNF-αlow/IL-8high	16	15 (7.8-NA)	40.1 (19-NA)
TNF-αhigh/IL-8low	16	15 (6-19.7)	26.7 (24.3-NA)
TNF-αhigh/IL-8high	19	6.3 (5.6-12.1)	16.7 (13.2-56.2)
TNF-α and IL-6	n	PFS (p<0.001)	OS (p=0.044)
TNF-αlow/IL-6low	17	11.2 (5.7-16.6)	25.4 (14.3-55.2)
TNF-αlow/IL-6high	18	18.1 (12.0-NA)	48.4 (26.5-NA)
TNF-αhigh/IL-6low	17	16.3 (9.4-NA)	26.1 (18.4-NA)
TNF-αhigh/IL-6high	18	6.2 (5.3-12.1)	25 (13.2-34)
	n	PFS (p=0.001)	OS (p=0.039)
All 3 high	13	6.0 (5.32-NA)	16.7 (6.31-NA)
All other combinations	57	15.0 (9.4-17.1)	30.2 (25.4-48.4)

NA: estimate does not drop below; p-values are 4-group log-rank tests; Italic = individually significant log-rank p<0.05