Table 2.
Allelic, genotypic and phenotype frequencies of CYP2C8 gene polymorphisms
| Allele | Genetic mutation | Enzyme activity | Number of alleles | Allelic frequency | 95% CI (±) | 95% CI range |
|---|---|---|---|---|---|---|
| *1 | Wild‐type | Normal | 266 | 0.806 | 0.043 | 0.763–0.849 |
| *2 | Missense | Decreased | 54 | 0.164 | 0.040 | 0.124–0.204 |
| *3 | Missense | Decreased | 6 | 0.018 | 0.014 | 0.004–0.033 |
| *4 | Missense | Decreased | 4 | 0.012 | 0.012 | 0.000–0.024 |
| *5 | Frame shift | None | 0 | 0.000 | 0.000 | |
| *7 | Missense | None | 0 | 0.000 | 0.000 | |
| *8 | Missense | Decreased | 0 | 0.000 | 0.000 | |
| Genotype | Number of subjects | Observed genotype frequency (%) | Expected genotype frequency (%) | Predicted phenotype | ||
| Wild‐type | ||||||
| *1/*1 | 110 | 66.7 | 65.0 | EM | ||
| Heterozygous | ||||||
| *1/*2 | 40 | 24.2 | 26.4 | IM | ||
| *1/*3 | 4 | 2.4 | 2.9 | IM | ||
| *1/*4 | 2 | 1.2 | 2.0 | IM | ||
| Subtotal | 46 | 27.8 | ||||
| Homozygous variant/compound heterozygous | ||||||
| *2/*2 | 5 | 3.0 | 2.7 | PM | ||
| *2/*3 | 2 | 1.2 | 0.6 | PM | ||
| *2/*4 | 2 | 1.2 | 0.4 | PM | ||
| *3/*3 | 0 | 0.0 | 0.0 | PM | ||
| *3/*4 | 0 | 0.0 | 0.0 | PM | ||
| Subtotal | 9 | 5.4 | ||||
| Total | 165 | 100 | 99.9 | |||
CI = confidence interval.