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. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: Biochemistry. 2015 May 15;54(21):3314–3319. doi: 10.1021/acs.biochem.5b00216

Figure 2.

Figure 2

Some of the many pathways that have been proposed 1: Igarashi & Seefeldt,14 2: Barney,17 3: Smith,19 and Morrison,20 Also, the pockets observed in this work P: Proximal, M: Medial, and D: Distal pockets. Residues labels are given to provide a frame of reference and outline the channel path. The CO in the dynamics calculations follows the channel predicted by Igarashi (labeled 1 in the figure).