Table 4.

Effect of 4 months of high-fat diet on mRNA of genes in white adipose tissue.

	WT		L-CC1
	RD	HF	RD	HF
Fatp-4	0.80 ± 0.10	1.80 ± 0.22*	0.96 ± 0.24	0.55 ± 0.11†
Lpl	1.20 ± 0.21	3.51 ± 0.30*	1.12 ± 0.12	1.25 ± 0.40†
Srebp-1c	1.09 ± 0.13	4.03 ± 0.70*	1.26 ± 0.51	0.94 ± 0.32†
Hsl	0.49 ± 0.10	0.80 ± 0.11*	0.51 ± 0.13	0.27 ± 0.14†
F4/80	8.85 ± 4.50	21.8 ± 2.61*	5.45 ± 1.22	9.08 ± 3.01*†
TNFα	2.75 ± 1.37	6.56 ± 0.78*	3.55 ± 0.78	3.01 ± 1.05†
Smad7	11.3 ± 2.56	1.72 ± 0.40*	15.2 ± 2.05	9.40 ± 2.04†
Col6α3	0.67 ± 0.11	1.58 ± 0.25*	0.58 ± 0.17	0.48 ± 0.13†
α-Sma	0.03 ± 0.01	1.05 ± 0.33*	0.06 ± 0.01	0.19 ± 0.05†

Mice (n > 5 per feeding group per genotype) were fed an HF diet for 4 months starting at 2 months of age.

Tissue mRNA levels were analyzed in duplicate per each mouse and normalized to 18S.

Values are expressed as mean ± SEM.

*P < 0.05 HF vs. RD per genotype.

^†P < 0.05 L-CC1 vs. WT per feeding group.