Figure 2.

Activation of the JAK/STAT3 pathway is a common feature of astrocyte reactivity in various ND models. Images of brain sections from several models of AD and HD (APP/PS1dE9 mice, 3xTg-AD mice, Hdh140 mice, and the murine and primate lenti-Htt82Q-based models of HD). For all ND models, STAT3 (green) accumulates in the nucleus of reactive astrocytes labeled with GFAP (red) in specific vulnerable regions (as indicated at the bottom). The first line shows the merged STAT3 (green)/GFAP (red) staining in age-matched control animals for each model. Scale bars: 20 μm (mouse) and 40 μm (primate). Adapted from Ben Haim et al. (2015).