Table 4. Risk factors for in-hospital death in patients with infective endocarditis.
| Univariate | Multivariate | |||
|---|---|---|---|---|
| Risk factors | P value | OR (95% CI) | P value | OR (95% CI) |
| Age ≥60 years old | 0.966 | 1.0 (0.2–5.1) | – | – |
| Male | 0.795 | 0.8 (0.2–3.4) | – | – |
| Smoking | 0.379 | 0.4 (0.0–3.2) | – | – |
| Community-acquired IE | 0.036 | 1 | 0.041 | – |
| Nosocomial IE | 0.026 | 8.1 (1.3–50.5) | 0.050 | 8.3 (1.0–69.0) |
| NNHCA-IE | 0.061 | 4.3 (0.9–19.5) | 0.034 | 6.5 (1.2–36.3) |
| Charlson comorbidity index ≥2 | 0.922 | 1.1 (0.2–5.4) | – | – |
| Predisposing cardiac conditions | 0.785 | 0.8 (0.2–3.1) | – | – |
| Prosthetic valve | 0.817 | 0.8 (0.1–6.5) | – | – |
| Congenital heart disease | 0.422 | 0.4 (0.1–3.5) | – | – |
| WBC> 10 × 109/L | 0.035 | 4.1 (1.1–15.5) | – | – |
| Serum creatinine levels>110 (μmol/L) | 0.225 | 2.8 (0.5–15.0) | – | – |
| Albumin levels (g/L) | 0.003 | 0.8 (0.7–0.9) | 0.04 | 0.8 (0.7–0.9) |
| Urine occult blood ≥3+ | 0.017 | 5.0 (1.3–19.0) | – | – |
| Mitral valve | 0.123 | 3.5 (0.7–17.0) | – | – |
| Aortic valve | 0.263 | 0.4 (0.1–2.0) | – | – |
| Vegetation | 0.500 | 0.6 (0.1–2.9) | – | – |
| Negative blood culture | 0.473 | 1.6 (0.4–6.0) | – | – |
| Streptococcus infectiona | 0.180 | 0.2 (0.0–2.0) | – | – |
| Staphylococcus infectiona | 0.130 | 1.9 (0.8–4.5) | – | – |
OR, odds ratio; CI, confidence interval; IE, infective endocarditis; NNHCA, non-nosocomial healthcare-associated; WBC, white blood cell.
a
Analysis was based on 108 positive cultures.