Table 3. Multivariate Cox models for OS in the common cohort.
| Parameters | Risk group | HR | 95% CI | P-valuea |
|---|---|---|---|---|
|
Clinical model | ||||
| Histologyb | 0.038 | |||
| Squamous | 2.336 | 0.954–5.718 | ||
| Other | 3.223 | 1.566–6.631 | ||
| Stage | IIIB–IV | 2.144 | 0.748–6.143 | 0.1558 |
| Surgery | No | 1.249 | 0.411–3.794 | 0.6949 |
|
Marker model | ||||
| LAMC2c | — | 1.449 | 1.098–1.912 | 0.0087 |
| CYFRA 21-1c | — | 1.387 | 1.148–1.676 | 0.0007 |
|
Full model | ||||
| Histologyb | 0.0262 | |||
| Squamous | 2.547 | 0.991–6.545 | ||
| Other | 2.361 | 1.118–4.984 | ||
| Stage | IIIB–IV | 1.655 | 0.473–5.785 | 0.4304 |
| Surgery | No | 1.353 | 0.372–4.919 | 0.6461 |
| LAMC2c | — | 1.344 | 1.021–1.769 | 0.0352 |
| CYFRA 21-1c | — | 1.398 | 1.126–1.736 | 0.0024 |
Abbreviations: CI=confidence interval; HR=hazards ratio; OS=overall survival.
a
Bold values are statistically significant (P<0.05).
b
Adenocarcinoma is the reference group (HR=1).
c
Markers were analysed as log transformed continuous variables.