Table 3. Labelling index of the different immune markers for each compartment and obtained by means of digital quantification.

	Mann-Whitney U-test (*significance at P<0.05)
Digital analysis	Median MSI	Lower quartile MSI	Upper quartile MSI	Median MSS	Lower quartile MSI	Upper quartile MSS	2 × one-sided exact P
CD3 tumour	0.043	0.014	0.090	0.020	0.016	0.037	0.06
CD3 peritumour	0.052	0.036	0.095	0.044	0.030	0.061	0.30
CD4 tumour	0.001	0.000	0.005	0.001	0.000	0.004	0.45
CD4 peritumour	0.006	0.002	0.018	0.004	0.001	0.008	0.29
CD8 tumour	0.016	0.007	0.051	0.005	0.005	0.013	0.02*
CD8 peritumour	0.021	0.014	0.032	0.014	0.007	0.023	0.03*
CD20 tumour	0.003	0.001	0.005	0.002	0.001	0.004	0.25
CD20 peritumour	0.019	0.008	0.030	0.013	0.006	0.031	0.73
CD68 tumour	—	—	—	—	—		—
CD68 peritumour	—	—	—	—	—		—

Abbreviations: MSI=microsatellite instability; MSS=microsatellite stable.

*P<0.05.