Table 2. Personal history of rosacea and risk of incident cancer (1991–2011).

	No Rosacea	Rosacea	Age-adjusted RR	Multivariable-adjusted RRa
Internal malignancies	1 382 634 person-years	64 571 person-years
Breast cancer	2998	186	1.07 (0.92–1.24)	1.03 (0.89–1.20)b
Thyroid cancer	331	29	1.54 (1.05–2.26)e	1.59 (1.07–2.36)e
Endometrial cancer	255	11	0.71 (0.38–1.29)	0.66 (0.35–1.22)
Colorectal cancer	215	12	0.87 (0.49–1.56)	0.85 (0.46–1.56)
Non-Hodgkin lymphoma	206	16	1.28 (0.77–2.14)	1.45 (0.85–2.45)
Ovarian Cancer	157	11	1.15 (0.62–2.13)	1.18 (0.63–2.23)
Other internal malignanciesc	720	47	1.10 (0.81–1.48)	1.19 (0.88–1.62)
Skin cancersd	1 344 071 person-years	60 007 person-years
Melanoma	344	16	1.04 (0.63–1.72)	0.96 (0.57–1.62)
Squamous cell carcinoma	418	34	1.32 (0.93–1.88)	1.30 (0.90–1.88)
Basal cell carcinoma	4552	424	1.57 (1.42–1.73)e	1.50 (1.35–1.67)e

^aAdjusted for age, body mass index (BMI), alcohol consumption, physical activity, physical examination, multivitamin use, smoking status, oral contraceptive use, menopausal status and postmenopausal hormone use, as well as history of severe teenage acne, use of medications including tetracycline, isotretinoin and antibiotics.

^bAdditionally adjusted for personal history of benign breast disease, family history of breast cancer, age at first birth and parity, age at menarche, height, and BMI at age 18 years.

^cOther individual cancers each with cases <100.

^dAdditionally adjusted for natural hair colour, childhood tendency to sunburn, number of sunburns at ages 15–20 years, family history of melanoma, self-reported mole count on lower legs, sun exposures at high school and at age 25–35 years, and UV index at birth, age 15, and age 30 years.

^eP<0.05.