Table 2. Univariate analysis of risk scores and bivariate analysis of CCP score with CAPRA score for death from prostate cancer and added value of CCP to CAPRA in the time intervals: 0–5 years, 5–10 years, and >10 years.
|
Univariate analysis |
Bivariate analysis |
||||||
|---|---|---|---|---|---|---|---|
| Variable | No. of men (deaths) | χ2 (1 df) | Hazard ratio (95% CI) | P-value | Δχ2 (1 df) | Hazard ratio (95% CI) | P-value |
|
CCP score | |||||||
| Overall | 585 (100) | 56.4 | 2.08 (1.76, 2.46) | 6.0 × 10−14 | 25.6 | 1.76 (1.44, 2.14) | 4.2 × 10−7 |
| 0–5 years | 585 (33) | 31.1 | 2.47 (1.87, 3.26) | 2.5 × 10−8 | 15.2 | 2.09 (1.49, 2.94) | 9.9 × 10−5 |
| 5–10 years | 483 (54) | 28.0 | 2.03 (1.62, 2.56) | 1.2 × 10−7 | 12.3 | 1.71 (1.30, 2.26) | 0.00046 |
| >10 years | 216 (13) | 1.08 | 1.38 (0.78, 2.46) | 0.30 | 0.28 | 1.20 (0.63, 2.28) | 0.60 |
|
CAPRA score | |||||||
| Overall | 585 (100) | 65.1 | 1.40 (1.28, 1.52) | 6.7 × 10−16 | 34.3 | 1.29 (1.18, 1.42) | 4.6 × 10−9 |
| 0–5 years | 585 (33) | 29.0 | 1.49 (1.27, 1.75) | 7.4 × 10−8 | 13.0 | 1.33 (1.12, 1.58) | 3.0 × 10−4 |
| 5–10 years | 483 (54) | 34.0 | 1.38 (1.23, 1.55) | 5.6 × 10−9 | 18.3 | 1.28 (1.14, 1.45) | 1.9 × 10−5 |
| >10 years | 216 (13) | 3.58 | 1.26 (0.98, 1.60) | 0.058 | 2.73 | 1.23 (0.96, 1.59) | 0.096 |
Abbreviations: CAPRA=Cancer of the Prostate Risk Assessment; CCP=cell cycle progression; CI=confidence interval; df=degrees of freedom; χ2=chi-square; Δχ2=added value of chi-square to cell cycle risk in bivariate analyses.
n=585. The overall χ2 for the bivariate model is 90.7 with two degrees of freedom.