Table 2. The relationship between chemosensitivity and the RNA expression levels of IMPs and Lin28/Lin28B (n=80).
IMP1 | IMP2 | IMP3 | Lin28B | Lin28 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
L | H | L | H | L | H | L | H | L | H | ||||||
Resistant | 20 | 20 | P=0.90 | 19 | 21 | P=0.50 | 13 | 27 | P=0.003 | 15 | 25 | P=0.04 | 22 | 17 | P=0.18 |
Sensitive | 21 | 19 | 17 | 23 | 26 | 14 | 24 | 16 | 17 | 24 |
Abbreviations: H=high expression, mRNA expression value over than median value; IMP=insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs; refered to as IMPs); L=low expression, mRNA expression value less than median value.
Sensitive was defined as a recurrence after a platinum-free interval ⩾6 months. Resistant was defined as a recurrence after a platinum-free interval of <6 months.