Table 2. Logistic Regression Analysis of Genetic Predictors of Postoperative Atrial Fibrillation in the Study Populations (Stage I).
| Discovery Cohort |
|||||||
|---|---|---|---|---|---|---|---|
| SNP | Gene/loci | Location | Alleles* | MAF (AF) | MAF (No AF) | OR (95% CI) | P |
| rs3740563 | GRK5 | Chr10:121095400 | C/A | 0.27 | 0.22 | 1.31 (1.09–1.58) | 0.005 |
| rs4752292 | GRK5 | Chr10:121100153 | G/T | 0.35 | 0.29 | 1.32 (1.11–1.57) | 1.98 × 10−3 |
| rs11198893 | GRK5 | Chr10:121107900 | G/A | 0.29 | 0.21 | 1.54 (1.27–1.85) | 6.87 × 10−6 |
| rs10787959 | GRK5 | Chr10:121131313 | G/A | 0.47 | 0.42 | 1.22 (1.04–1.44) | 0.016 |
| rs2200733 | 4q25 | Chr4:111929618 | C/T | 0.42 | 0.39 | 1.13 (0.96–1.34) | 0.145 |
| rs13143308 | 4q25 | Chr4:111933868 | T/G | 0.27 | 0.32 | 0.79 (0.65–0.94) | 9.73 × 10−3 |
| rs10033464 | 4q25 | Chr4:111940210 | G/T | 0.25 | 0.21 | 1.25 (1.03–1.52) | 0.022 |
| rs1800795 | IL6 | Chr7:22727026 | G/C | 0.07 | 0.06 | 1.18 (0.85–1.64) | 0.327 |
| rs2227956 | HSP70 | Chr6:31810495 | T/C | 0.21 | 0.19 | 1.13 (0.92–1.39) | 0.230 |
*Major allele/minor allele.
P value in bold means statistically significant.