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. 2015 Aug 3;5:11593. doi: 10.1038/srep11593

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The yellow histogram shows the distributions of the Wald statistic (Z) for the 1,000 resampled gene signatures picked up from human genome with identical size as iCG. The blue histogram shows the distributions of the Z for the 1,000 resampled gene signatures selected from the glioma-associated genes. The black triangles stand for the Z values of iCG. Right-tailed P-values of the sampling distribution were calculated.