Figure 7. In silico modeling of AHR ligand binding domain.
Homology modeling of indirubin optimized ligand binding in (A) hAHR and (B) mAHR. The predicted two indole-binding model in (C) hAHR and (D) mAHR ligand binding domain. The predicted two 3-methyl indole-binding models in (E) hAHR and (F) mAHR ligand binding domain. Blue shading indicates the space-filling volume of the ligand binding pocket.