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Model of 4EGI-1’s action in cells. (A) Cellular concentrations of eIF4G versus unphosphorylated 4E-BP1 determine which of the two ligands bind to eIF4E, thus activating or inhibiting translation initiation. (B) Addition of 4EGI-1 destabilizes eIF4G binding. (C) When the drug is present during translation and 4E-BP1 is hyperphosphorylated (cannot bind to eIF4E), 4EGI-1 will bind to eIF4E, causing eIF4G to dissociate from eIF4E, inhibiting translation.
