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. 2015 Jul 13;112(30):E4036–E4045. doi: 10.1073/pnas.1512118112

Fig. S5.

Fig. S5.

Overview of motif 1 (encompassing 54YXXXXLΦ60), centered on 4E-BP1 Y54. (A) 4E-BP1 and eIF4E are, respectively, represented in blue and red. The hydroxyl group of 4E-BP1 Y54 is hydrogen bonded with eIF4E P38 whereas its aromatic ring is surrounded by the side chains of F58 and L59 in 4E-BP1 and by the side chain of V69 of eIF4E. (B) Overlay (centered on motif 1) of eIF4E33–217/m7GTP/4E-BP144–84 structure with another eIF4E/m7GpppA/4E-BP136–70 structure (PDB ID code 1WKW) described by Tomoo et al. (22), where eIF4E and 4E-BP1 are, respectively, in cyan and pink. Structures were aligned using PyMOL, showing a dorsal view of the complex.