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Schematic depiction of the dual luciferase assay used throughout this work. Plasmid psiCheck-2 coencodes Renilla and Firefly luciferases. Renilla was tagged with specific shRNA- or miR-122–binding sites because of its higher sensitivity, and Firefly was used for normalization. m7G, 7-methylguanylate cap (5′ end of mRNAs); R/Fluc, Renilla/Firefly luciferase; RISC, RNA-induced silencing complex; p(A), poly(A) tail.
