Fig. 6.

Two-step model for neuronal migration during adult hippocampal neurogenesis. During adult hippocampal neurogenesis, radial glia-like cells give rise to Tbr2⁺ intermediate progenitor cells within 3 d. In the next 4 d, the cells become DCX⁺ proliferating neuroblasts that extend long processes tangential to the SGZ and contact blood vessels directly. During this phase, neuroblasts use blood vessels as a substrate to migrate tangentially away from their parental RGL. After 7 d, newborn neural progeny extend radial dendritic processes and develop into NeuN⁺Prox1⁺ dentate granule neurons and exhibit limited radial migration through the granule cell layer. (Lower) Global-view illustration of RGLs, neural progeny, and vasculature in the adult SGZ.