Table S1.
Ordinary differential equation parameters
| Parameter | Value | Description | Corresponding interaction | Source |
| kdBax | 0.0001 | Degradation rate of activated Bax | bax*_deg | (27) |
| kdtBid | 0.0001 | Degradation rate of tBid | tbid_deg | Same as kdBax |
| k3 | 0.000015 | Activation rate of Bax by membrane binding tBid | tbidMOM_act_bax | (50) |
| k16 | 0.00001 | Activation rate of Bax by membrane binding Bax dimer | baxMOM^2_act_bax | Estimated from k3 |
| k2 | 0.0004 | Association rate of membrane binding tBid and Bcl2 | tbidMOM* bcl2 | (41) |
| kf2 | 0.002 | Dissociation rate of membrane binding tBid and Bcl2 | tbidMOM − bcl2 | (41) |
| k4 | 0.0002 | Association rate of membrane binding Bax and Bcl2 | baxMOM* bcl2 | (41) |
| kf4 | 0.003 | Dissociation rate of membrane binding Bax and Bcl2 | baxMOM − bcl2 | (41) |
| k12 | 0.0002 | Association rate of membrane binding Bax | baxMOM* baxMOM | Estimated from k4 |
| kf12 | 0.003 | Dissociation rate of membrane binding Bax | baxMOM − baxMOM | Estimated from kf4 |
| k14 | 0.0002 | Association rate of membrane binding Bax dimer | baxMOM^2* baxMOM^2 | Estimated from k4 |
| kf14 | 0.003 | Dissociation rate of membrane binding Bax dimer | baxMOM^2 − baxMOM^2 | Estimated from kf4 |
| k18 | 0.0005 | Association rate of membrane binding Puma and Bcl2 | pumaMOM* bcl2 | (41) |
| kf18 | 0.002 | Dissociation rate of membrane binding Puma and Bcl2 | pumaMOM − bcl2 | (41) |
| k5 | 0.002 | Production rate of Bid | bid_pro | Estimated from (ref. 27) |
| kf5 | 0.0001 | Degradation rate of Bid | bid_deg | Same as kdBax |
| k6 | 0.02 | Production rate of Bax | bax_pro | Estimated from (ref. 27) |
| kf6 | 0.0001 | Degradation rate of Bax | bax_deg | Same as kdBax |
| k7 | 0.008 | Production rate of Bcl2 | bcl2_pro | Estimated from (ref. 27) |
| kf7 | 0.0001 | Degradation rate of Bcl2 | bcl2_deg | Same as kdBax |
| k17 | 0.001 | Production rate of Puma | puma_pro | Estimated |
| kf17 | 0.0001 | Degradation rate of Puma | puma_deg | Same as kdBax |
| kf8 | 0.0001 | Degradation rate of membrane binding tBid | tbidMOM_deg | Same as kdBax |
| kf9 | 0.0001 | Degradation rate of membrane binding Bax | baxMOM_deg | Same as kdBax |
| kf10 | 0.0001 | Degradation rate of Bcl2·tBidMOM complex | bcl2·tbidMOM_deg | Same as kdBax |
| kf11 | 0.0001 | Degradation rate of Bcl2·BaxMOM complex | bcl2·baxMOM_deg | Same as kdBax |
| kf13 | 0.0001 | Degradation rate of Bax dimer | baxMOM·baxMOM_deg | Same as kdBax |
| kf15 | 0.0001 | Degradation rate of Bax oligomer | baxMOM^2·baxMOM^2_deg | Same as kdBax |
| kf19 | 0.0001 | Degradation rate of Bcl2·tBidMOM complex | bcl2·pumaMOM_deg | Same as kdBax |
| kBidon | 0.0002 | Membrane translocation rate of tBid | tbid_onMOM | Estimated from cell size |
| kBidoff | 0.00002 | Membrane separation rate of tBid | tbid_offMOM | Estimated from cell size |
| kBaxon | 0.0002 | Membrane translocation rate of active Bax | bax*_onMOM | Same as kBidon |
| kBaxoff | 0.00002 | Membrane separation rate of active Bax | bax*_offMOM | Same as kBidoff |
| kPumaon | 0.0002 | Membrane translocation rate of Puma | puma_onMOM | Same as kBidon |
| kPumaoff | 0.00002 | Membrane separation rate of Puma | puma_offMOM | Same as kBidoff |
| kdPuma | 0.0001 | Degradation rate of membrane binding Puma | pumaMOM_deg | Same as kdBax |
| k24 | 0.0004 | Association rate of A1 and active Bax | A1* bax* | (41) |
| kf24 | 0.004 | Dissociation rate of A1 and active Bax | A1 − bax* | (41) |
| k25 | 0.0005 | Association rate of A1 and Puma | A1* puma | (41) |
| kf25 | 0.002 | Dissociation rate of A1 and Puma | A1 − puma | (41) |
| k26 | 0.0002 | Association rate of A1 and tBid | A1* tbid | (41) |
| kf26 | 0.001 | Dissociation rate of A1 and tBid | A1 - tbid | (41) |
| k27 | 0.0002 | Association rate of A1 and Noxa | A1* noxa | (41) |
| kf27 | 0.003 | Dissociation rate of A1 and Noxa | A1 - noxa | (41) |
| kA1 | 0.003 | Production rate of A1 | A1_pro | Estimated from (ref. 27) |
| kdA1 | 0.0001 | Degradation rate of A1 | A1_deg | Same as kdBax |
| kdA1Bax | 0.0001 | Degradation rate of A1·Bax complex | A1·bax_deg | Same as kdBax |
| kdAPuma | 0.0001 | Degradation rate of A1·Puma complex | A1·puma_deg | Same as kdBax |
| kdA1tBid | 0.0001 | Degradation rate of A1·tBid complex | A1·tbid_deg | Same as kdBax |
| kdA1Noxa | 0.0001 | Degradation rate of A1·Noxa complex | A1·noxa_deg | Same as kdBax |
| kNoxa | 0.001 | Production rate of Noxa | Noxa_pro | Estimated from (ref. 27) |
| kdNoxa | 0.0001 | Degradation rate of Noxa | Noxa_deg | Same as kdBax |
| Beta | 2 | Constant of cell volume normalization | — | — |
| k1 | 0.0000012 | Activation rate of Bid by caspase8 | — | Estimated from k3 |
| C8 | Changing | Concentration of caspase8 | Control parameter | — |