Table S4.

Regions of functional interaction domains and mutations

Protein	interaction	Functional domain region for interaction (amino acids)	Mi	Li	Mnon_fun	Lnon_fun	Mutation enrichment
BID	Bid · A1	90–98	2	9	5	130	4.412698413
	Bid · Bcl2	90–98	2	9			4.412698413
	Bid_MOM	145–192	3	48			1.390625
BAX	Bax · A1	57–82	2	26	3	40	1.015384615
	Bax · Bax	54–122	5	69			0.987318841
	Bax_MOM	168–192	4	25			1.485714286
	Bax · Bcl2	57–82	2	26			1.015384615
	(Bax)2 · (Bax)2	107–147	3	48			0.916666667
BCL2	Bcl2 · Bid	100–157	20	58	24	70	1.003134796
	Bcl2 · Bax	100–157	20	58			1.003134796
	Bcl2 · Puma	100–157	20	58			1.003134796
PUMA	Puma · A1	131–153	0	23	1	140	0
	Puma · Bcl2	141–149	0	9			0
	Puma_MOM	150–192	4	43			3.404651163
A1	A1 · Bax	40–99	2	60	9	70	0.393939394
	A1 · Puma	40–99	2	60			0.393939394
	A1 · Noxa	40–99	2	60			0.393939394
	A1 · Bid	40–99	2	60			0.393939394
NOXA	Noxa · A1	29–37	0	9	0	35	0