Table 2.
Comparison of αO-GeXIVA with selected conotoxins
| Toxin | Source | Sequence | Target | Mass, Da | Source |
| αO-GeXIVA | C. generalis | TCRSSGRYCRSPYDRRRRYCRRITDACV* | α9α10 nAChR >> α1β1δε ∼ α7 ∼ α*β2 nAChRs > α*β4 nAChRs | 3,452 | This study |
| αB-VxXXIVA | C. vexillum | VRCLEKSGAQPNKLFRPPCCQKGPSFARHSRCVYYTQSRE* | α9α10 nAChR > Mouse α1β1γδ | 4,623 | (71) |
| Conantokin-Br (con-Br) | C. brettinghami | GDγγYSKFIγRERγAGRLDLSKFP* | NMDAR, NR2B > NR2D > NR2A > NR2C | 3,046 | (72) |
| Mr8.2 | C. marmoreus | ALVSQCRPCPTCRECKCRECKCRECQCRIHSCLSAWDSRGIWMRT | ND | 5,280 | (73) |
| ω-MVIIA | C. magus | CKGKGAKCSRLMYDCCTGSCRSGKC† | Cav2.2 > Cav2.1 | 2,637 | (74, 75) |
| pl14a (κJ-PlXIVA) | C. planorbis | FPRPRICNLACRAGIGHKYPFCHCR† | kV 1.6 > 1.1 > 1.2 ∼ 1.3 ∼ 1.4 ∼ 1.5 ∼ 2.1 ∼ 3.4 | 2,909 | (76, 77) |
| pl14a (αJ-PlXIVA) | Muscle > α3β2 nAChRs | ||||
| lt14a (αL-LtXIVA) | C. litteratus | MCPPLCKPSCTNC† | ND (inhibits contraction of the frog muscle) | 1,391 | (78) |
| vil14a (κL-VilXIVA) | C. villepinii | GGLGRCIYNCMNSGGGLSFIQCKTMCY* | ND | 2,871 | (40) |
| ψ-PIIIE | C. purpurascens | HOOCCLYGKCRRYOGCSSASCCQR† | Muscle nAChR | 2,715 | (79, 80) |
| α-LtIA | C. litteratus | GCCARAACAGIHQELC† | α3β2 > α6/α3β2β3 | 1,600 | (81) |
| αA-EIVA | C. ermineus | GCCGPYONAACHOCGCKVGROOYCDROSGG† | Muscle nAChR | 3,094 | (82) |
| αC-PrXA | C. parius | TYGIYDAKPOFSCAGLRGGCVLPONLROKFKE† | Muscle nAChR | 3,539 | (83) |
| αD-VxXXB | C. vexillum | DDγSγCIINTRDSPWGRCCRTRMCGSMCCPRNGCTCVYHWRRGHGCSCPG (dimer) | α7 > α3β2 | 5,735 | (84) |
| αS-RVIIIA | C. radiatus | KCNFDKCKGTGVYNCGγSCSCγGLHSCRCTYNIGSMKSGCACICTYY | Muscle nAChR | 5,167 | (85) |
| Neuronal nAChR |
C., Conus; ND, not determined; O, hydroxyproline; γ, γ-carboxyglutamate (Gla).
*
C terminus COOH.
†
C terminus amidation.