Table 1.
Somatic mutations in H5-specific Abs and bnAbs
| Antibody | Epitope* | No. of variable domain mutations | ||
| Heavy chain | Light chain | Total | ||
| H5-specific Abs | ||||
| H5.2 | Head | 10 | 8 | 18 |
| H5.3 | Head | 4 | 7 | 11 |
| H5.7 | Stem | 5 | 2 | 7 |
| H5.13 | Head | 4 | 2 | 6 |
| H5.16 | n.d. | 9 | 7 | 16 |
| H5.24 | n.d. | 6 | 10 | 16 |
| Avg | 12.3 | |||
| SD | 5.1 | |||
| bnAbs | ||||
| CH65 | Head | 12 | 6 | 18 |
| CH67 | Head | 10 | 9 | 19 |
| C05 | Head | 22 | 14 | 36 |
| CR6261 | Stem | 15 | 3 | 18 |
| CR8020 | Stem | 13 | 8 | 21 |
| FI6 | Stem | 14 | 9 | 23 |
| CR9114 | Stem | 17 | 12 | 29 |
| F045-092 | Head | 13 | 9 | 22 |
| H5.9 | n.d. | 16 | 11 | 27 |
| H5.31 | Head | 9 | 7 | 16 |
| H5.36 | n.d. | 2 | 7 | 9 |
| Avg | 21.6 | |||
| SD | 7.2 | |||