Burden of chronic disease rises exponentially with age. To examine the association between age and disease burden, we accessed data from the Institute for Health Metrics and Evaluation Global Burden of Disease database (www.healthdata.org/gbd) (43). Data graph (A) disability-adjusted life years (DALYs) and (B) deaths per 100,000 population by age. Bars, from bottom to top, reflect the burden of cardiovascular disease (navy), type-2 diabetes (light blue), stroke (lavender), chronic respiratory disease (red), and neurological disorders (purple).