Fig. S3.

Primary sequence alignment of nsp14 homologs by ClustalW (53) and rendered using ESPript version 3.0 (54). The secondary structural elements and numbering of SARS-CoV nsp14 are displayed above the alignment. Identical residues in all sequences are boxed with red background; those conserved are marked in red. Catalytic residues, D243, and residues involved in formation of zinc fingers are marked with magenta stars, red stars, and green triangles, respectively. Sequences of nsp14 in SARS-CoV (accession number ADC35510), MERS-CoV (AIZ48758), mouse hepatitis virus (MHV; NP_068668), human coronavirus [(HCoV)-229E; (AGT21366.1], and infectious bronchitis virus (IBV; P0C6Y2) were used for the analysis.