Fig. S6.

4LB5 cytotoxic effect depends on surface-NCL expression and is prevented by overexpression of specific miRNAs. (A) MDA-MB-231 cells were transfected with control (siC) or anti-NCL (siNCL) siRNAs for 24 h, and then untreated or treated with 30 nM 4LB5 for 48 h. Total cells were counted. Data are representative of three independent experiments performed in quadruplicate. Mean ± SD is reported. **P < 0.01. (B) MDA-MB-231 cells were transfected with scramble RNA or indicated mature miRNAs for 24 h, and treated or not with 50 nM 4LB5 for 48 h. Total cells were counted. Data are representative of two independent experiments performed in quadruplicate. Mean ± SE is reported. *P < 0.05.