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. 2015 Jul 15;112(30):E4129–E4137. doi: 10.1073/pnas.1511910112

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Fig. S1. — Loss of LGI1 also results in decreased AMPAR-mediated transmission in dentate gyrus granule cells. (A) Loss of LGI1 leads to a significant decrease in AMPA/NMDA ratio in dentate gyrus (DG) granule cells (P = 0.02, n = 11 wild type, 8 LGI1^−/−). (Left) Sample traces of wild-type (black) and LGI1^−/− (gray) neurons recorded at −70 mV and +40 mV. (Scale bar, 50 ms and 50 pA.) (Right) Bar graphs showing average AMPA/NMDA ratios ± SEM in wild type and LGI1^−/−. (B) Loss of LGI1 has no impact on paired-pulse ratio recorded in the dentate gyrus (P = 0.96, n = 9 wild type, 8 LGI1^−/−). (Left) Sample traces normalized to first-response amplitude in wild-type cell. (Scale bar, 40 ms.) (Right) Average ratio ± SEM.