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Model figure. Tumorigenicity is largely an intrinsic property of the cell. However, tumorigenicity can also be gained or lost as a result of stochastic fluctuations. This transition is governed by epigenetic regulation through LSD1. Low LSD1 expression is associated with high MYC locus H3K4me3, which promotes high expression of MYC and downstream MYC target genes including OLIG2, POU3F2, and SOX2. These factors, in turn, promote a tumorigenic cell state.
